Articles and Research Papers
Explore the science behind gut health and neurodevelopment.
A Comprehensive Review of the Neurological Manifestations of Celiac Disease and Its Treatment
Celiac disease often presents with extra‑intestinal symptoms—up to half of patients experience neurological issues like ataxia, cognitive impairment, epilepsy, headaches, and neuropathy. The review emphasizes the efficacy of a lifelong gluten-free diet in improving many of these symptoms and highlights the need to consider celiac disease even in young patients with unexplained neurological signs.
Celiac Disease, Beyond the Bowel: A Review of Its Neurological Manifestations
This review discusses how gluten-related disorders extend into the neurological sphere, covering conditions like gluten ataxia, peripheral neuropathy, encephalopathy, and epilepsy. It explores potential mechanisms—such as antibody cross-reactivity and neuroinflammation—and underscores how symptoms often resolve with strict gluten elimination.
Disturbance of Gut Bacteria and Metabolites Are Associated with Disease Severity and Predict Outcome of NMDAR Encephalitis
In children and adults with anti‑N‑methyl‑D‑aspartate receptor (NMDAR) encephalitis, researchers found altered gut microbiome profiles and metabolite patterns that correlate with disease severity and predict relapse risk. Lower microbiome diversity was linked to more severe outcomes, highlighting a gut–brain–immune axis in non-celiac neurological conditions.
Gut Microbiome Changes in Anti‑NMDAR Encephalitis
This study documented lower bacterial diversity in pediatric anti‑NMDAR encephalitis compared to healthy children, particularly with Prevotella increases and Bacteroides decreases. Whether these changes are causes or effects remains under investigation.
Gut–Brain Connection in Autism
This narrative review summarizes recent findings on how gut microbiota influences the gut–brain axis in Autism Spectrum Disorder (ASD). It covers dietary strategies like gluten‑free or antioxidant-rich diets, probiotic use, and potential therapies such as fecal microbiota transplantation (FMT). While results are promising, the paper emphasizes the need for more long-term, personalized studies.
A Robust Microbiome Signature for ASD
Using machine learning on 16S rRNA data from three cohorts, this study identifies 26 bacterial taxa that can distinguish ASD from neurotypical siblings with over 80% accuracy. The findings suggest a strong microbiome–ASD connection and highlight gut bacteria as a potential therapeutic target.
Multi-level Gut–Brain Axis Analysis in ASD
Integrating microbiome, metabolomics, cytokines, and brain gene expression from ten cohort studies, this research reveals ASD-specific molecular and bacterial profiles. Key findings show shifts in amino acid, carbohydrate, and lipid metabolites tied to species like Prevotella and Bacteroides—offering a systems-level view of how gut changes may relate to behavior.